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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NME2
All Species:
52.42
Human Site:
Y52
Identified Species:
88.72
UniProt:
P22392
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22392
NP_001018146.1
152
17298
Y52
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
Chimpanzee
Pan troglodytes
XP_001147407
308
33377
Y208
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
Rhesus Macaque
Macaca mulatta
XP_001096144
240
26905
Y140
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
Dog
Lupus familis
XP_533973
152
17223
Y52
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
Cat
Felis silvestris
Mouse
Mus musculus
Q01768
152
17345
Y52
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
Rat
Rattus norvegicus
P19804
152
17264
Y52
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515701
267
30034
Y167
E
E
H
L
Q
Q
H
Y
I
D
L
K
D
R
P
Chicken
Gallus gallus
O57535
153
17269
Y53
E
D
L
L
K
Q
H
Y
I
D
L
K
D
R
P
Frog
Xenopus laevis
P70011
154
17484
Y53
Q
D
L
L
R
Q
H
Y
I
D
L
K
D
R
P
Zebra Danio
Brachydanio rerio
NP_571001
153
17215
Y53
E
D
L
L
K
Q
H
Y
I
D
L
K
D
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08879
153
17151
Y53
K
E
L
L
E
K
H
Y
A
D
L
S
A
R
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LAH8
237
25755
Y135
K
G
F
A
Q
K
H
Y
H
D
L
K
E
R
P
Baker's Yeast
Sacchar. cerevisiae
P36010
153
17148
Y53
D
K
L
L
E
Q
H
Y
A
E
H
V
G
K
P
Red Bread Mold
Neurospora crassa
Q9UUY8
152
16882
Y52
Q
A
H
L
E
K
H
Y
E
D
L
N
T
K
P
Conservation
Percent
Protein Identity:
100
46.4
57
84.8
N.A.
98
98
N.A.
54.3
91.5
86.3
86.9
N.A.
77.1
N.A.
N.A.
N.A.
Protein Similarity:
100
47.7
60.8
92.1
N.A.
99.3
99.3
N.A.
55.8
96
94.8
92.8
N.A.
86.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
80
N.A.
100
100
N.A.
93.3
86.6
73.3
86.6
N.A.
53.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
73.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
60.1
63.1
Protein Similarity:
N.A.
N.A.
N.A.
51
79
79.6
P-Site Identity:
N.A.
N.A.
N.A.
46.6
33.3
46.6
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
66.6
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
0
0
15
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
36
0
0
0
0
0
0
0
93
0
0
72
0
0
% D
% Glu:
65
43
0
0
22
15
0
0
8
8
0
0
8
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
43
0
0
0
100
0
8
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
0
% I
% Lys:
15
8
0
0
58
22
0
0
0
0
0
79
0
15
0
% K
% Leu:
0
0
50
93
0
0
0
0
0
0
93
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% P
% Gln:
15
0
0
0
15
65
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
0
0
0
86
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _